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However, intranasal administration is also considered an efficient route for systemic effects due to the dense vasculature of the nasal mucosa

Western blotting also showed that suppressing c-Met expression downregulates the expression of NGF, N-cadherin, and Vimentin but upregulated the expression of E-cadherin (Fig

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The effect is likely explained by an increased unmeasured comorbidity burden in the high BBB-permeability group, which should in principle also raise the Alzheimer's risk, 73 thereby reducing our effect size

Although brain infarction volume reduction did not reach statistical significance, motor performance in the rotarod test significantly recovered in DSIP-treated animals compared to vehicle controls confirming a functionally relevant neuroprotective effect at the behavioural level and establishing intranasal delivery as a viable route for CNS DSIP research

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