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Research has shown that many cancers overexpress ACSL4 ( 4.1.2 Epithelial-mesenchymal transition There is crosstalk between the signaling pathways associated with epithelial-mesenchymal transition (EMT) and those involved in ferroptosis

d Achieved significance with the early stage group

Carotenoids are capable to scavenge lipid peroxy-radicals and singlet oxygen and inhibit superoxide generation and lipid peroxidation under drought stress 48

Finally GSSG is reduced by glutathione reductase (GR) using NADPH as the electron donor

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