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In the NEJM Phase 2 trial, participants assigned to an initial dose of 4 mg experienced significantly more adverse events than those who started at 2 mg, even when both groups ultimately reached the same target dose

Results will continue to improve with daily use

[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Brautigam L, et al

196 To achieve therapeutic concentrations at the tumor site, drug doses often need to be escalated toward maximum tolerated levels to generate sufficient bloodtumor concentration gradients

They often indicate compromises in the purification process, resulting in a lower-purity product that is unsuitable for serious research

Daily equimolar dosing of gel-forming drops (freshly prepared every 14 days) containing the polymer only (vehicle) or with 112 mM NAC or 112 mM NACET (21.5 mg/mL) was initiated when the eyes opened at P14