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Normal Saline contains chloride ions that interact with the positively charged polymyxin molecule, leading to drug degradation and reduced antibacterial activity during prolonged infusion

J Neuropathol Exp Neurol 65(6):56270 Booij L et al (2005) The effects of high-dose and low-dose tryptophan depletion on mood and cognitive functions of remitted depressed patients

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[0001842] Administered in combination: As used herein, the term "administered in combination" or "combined administration" means that two or more agents are administered to a subject at the same time or within an interval such that there may be an overlap of an effect of each agent on the patient

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