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It was shown that the deletion of E155 in GSTO1-1 has a significant effect on enzymatic stability and may consequently alter the physiologic role of the enzyme in the brain regions 53

They promote macrophage polarization to the M2 anti-inflammatory phenotype, inhibit inflammatory pathways, and may improve skin barrier function, offering theoretical benefits in RA, IBD, and psoriasis

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Moreover, Zhang et al

Similarly, peroxisome proliferator-activated receptor (PPAR)- agonists such as fenofibrate promote fatty acid oxidation, which may help clear the lipid accumulation associated with mitochondrial dysfunction and reduce inflammation-driven atherosclerosis (159)