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CONCLUSIONS Although the genetic markers did not contribute to smoking cessation treatment, we showed that starting smoking cessation treatment with the most effective drug, varenicline, and then adding bupropion at Week 4 for those who were not able to achieve smoking cessation by then, led to an excellent smoking cessation rate and reduced the chances of unnecessary drug administration and increased adverse events.

Quitting resources should provide multiple options for smokers to choose the method that works best for them

In turn, it is based on the Otto et al (2015) model

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