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GSTs are involved in the main detoxification route of AFB1- exo -8,9-epoxide by catalyzing the conjugation of AFB1- exo -8,9-epoxide to endogenous GSH

Caloric restriction mimetics or SIRT6 overexpression alleviated ischemic and reperfusion-induced brain injury in vitro

Bidirectional transmission in the GBA plays a major role in modulating brain dysfunction, maintaining symbiosis with the host and modulating innate as well as adaptive immune responses The normal gut microbiota synthesizes microbial metabolites and neurotransmitters that interact with host cells including intestinal epithelial cells (IECs) and immune cells

Despite their ecological importance, many steps of the biosynthetic pathways of cardiac glycosides remain unknown