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If results indicate inferior PK propertiessuch as high clearance, short half-life (t 1/2 ) and/or low bioavailabilityPD effects will likely be sub-optimal

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The effect size is modest and highly context dependent

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Interestingly, expression of pro-inflammatory cytokines (e.g., IL-6 and TNF) was significantly reduced in male rat livers compared to females after LPS administration, a response that correlated with enhanced survival (95)

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