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Description

A defining pathological feature of FRDA is the paradoxical accumulation of iron within mitochondria despite systemic iron dysregulation

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Using a p38 inhibitor like SB202190 can disrupt this coupling, thereby promoting CTC awakening [131]

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References Matthews CK, van Holde KE

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Electrophysiological characterization of the prokinetic agents cisapride and mosapride in vivo and in vitro: implications for proarrhythmic potential

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