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It is a well-studied pathway in higher eukaryotes but little is known about it in the malaria parasite 13

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Women with hormonal drivers (especially around perimenopause and menopause) should also get a hormone evaluation, since addressing underlying hormonal shifts is often part of an effective protocol

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For comparative purposes, aminoguanidine, a recognized protein oxidation inhibitor, and N-acetylcysteine (NAC), an antioxidant, were employed alongside amlodipine