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Free radicals are a natural product of normal metabolic processes and are essential to the inflammatory process that enables wound healing and muscular adaptation from training

These cells, in turn, secrete cytokines and ROS, further enhancing ferroptosis (108)

The latter scenario points to the essential role of oxidant stress as an amplifying process of cell death signaling

This discovery represented a major advance in understanding enzymatic antioxidant defence mechanisms and highlighted the biological importance of selenium, which was later recognised as an essential trace element due to its role in selenoproteins such as GPx

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