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This results in HIF-1 translocation into the nucleus, where in a complex with HIF-1 it activates transcription via binding to hypoxia responsive elements (HRE) in the promoters of corresponding genes (Kim et al., 2021)

10.1002/hep.510250413 Hepatology 134 UnicA.DerekL.DuvnjakM.PatrljL.RakicM.KujundzicM.et al (2018)