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The Cala TWO trial will be available at the following two locations: PNI- Santa Monica: 2125 Arizona Avenue, Santa Monica, CA 90404 PNI- South Bay: 4201 Torrance Blvd., Suite 520, Torrance, CA 90503 For more information and to enroll into the trial, please contact Giselle Tamula, NP, at [email protected]

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However, activation of the IKK kinase complex results in IB degradation, facilitating NF-B nuclear translocation and upregulation of pro-inflammatory genes, including Interferon gamma (IFN-), transforming growth factor beta (TGF-), interleukin (IL)-1, monocyte chemoattractant protein 1 (MCP-1), IL-6 and TNF-

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