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Vitamin B(12) deficiency and depression in physically disabled older women: epidemiologic evidence from the Women's Health and Aging Study

It emphasises the importance of recognising a wide range of symptoms and signs that could indicate a deficiency - including cognitive difficulties, such as: Eyesight problems Mental health issues Neurological/mobility problems Unexplained fatigue The guidelines highlight the necessity for an initial diagnostic test for suspected vitamin B12 deficiency, utilising either total B12 or active B12 tests, (unless specific circumstances require an alternative approach)

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However, the molecular events that promote these alterations are incompletely understood (6)