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Substrate stress relaxation regulates cell spreading

Diabetologia 48 , 838848 (2005)

10.1002/2211-5463.70129 124 PokhrelS.DeviS.GestwickiJ

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In contrast to purines that are synthesized as ribonucleotides rather than as nucleobases, pyrimidines are synthesized first as nucleobases and then conjugated to phosphoribosyl pyrophosphate (PRPP) to yield the corresponding ribonucleotide