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For traumatic brain injury, the CAPTAIN program, summarized in a 2021 meta-analysis of two randomized trials and 185 patients, likewise reported modest benefit (Vester et al., 2021, pooled RCTs)

Large-scale CRISPR-based screens have identified thousands of degron motifs, particularly at protein C-termini, regulated by Cullin-RING E3 ligase complexes such as CRL2 and CRL4