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The study was funded by Cancer Research UK

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METHODS This study followed the PRISMA-ScR guidelines and the Arksey and OMalley 20 five-step framework for literature search, screening, extraction, and synthesis 21

Cardiovascular toxicity A study by PMI researchers showed that IQOS exposure had 18 times fewer inhibitory effects than CS on chemotaxis and trans-endothelial migration of human coronary arterial endothelial cells as a marker of cardiovascular health 27