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Stability can be affected by formulation, storage, heat and oxidation

tricornutum significantly increased under high C: N conditions, along with the differential expression of carbon and nitrogen metabolism-related proteins [11]

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Response: We interpret both comments as suggesting that CMS perform two versions of Shared Savings Program calculationsone that makes adjustments for SAHS billing activity and one that does notand then issuing initial determinations based on the version of the calculations that would result in an ACO maximizing their shared savings or minimizing their shared losses for the performance year

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