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may progress to hemorrhagic shock Tachypnea compensatory respiratory response Decreased urine output in hypovolemic states from acute blood loss Koilonychia (spoon nails) and glossitis classic signs of chronic iron deficiency anemia Pica craving for non-food items (ice, clay, dirt) seen in severe iron deficiency Polycythemia Pruritus after bathing (aquagenic pruritus) characteristic of polycythemia vera

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However, certain medications and substances may still interact with methylcobalamin, potentially altering its absorption or effectiveness

Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status

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Being me (sciencey minded) I've done my own trials on myself with in-date and out-of-date ampoules and found no difference