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(Table adapted from Tang et al ., 2021) Calcium Pathway Dysregulated ORAI1-mediated Ca 2+ influx contributes to ferroptosis induced by GSH depletion

We aim to offer both the principles underlying cellular dependence on glutamine metabolism under various conditions and a discussion of future directions that are leading our efforts to investigate the role of glutamine in cellular metabolism

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Hepatic S -adenosylmethionine levels were reduced by 50%, whereas methionine, GSH, and cysteine levels were reduced by 7080%

Douce, R., Bourguignon, J., Neuburger, M., & Rbeill, F