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This phosphorylation signals the degradation of IB, enabling NF-B to be released and migrate to the nucleus

The incidence of adrenal medullary hyperplasia and pheochromocytoma increased in male rats given 1 mg/kg/day (below clinical exposure at the maximum recommended human dose [MRHD] based on AUC) and in female rats at all dose levels (below clinical exposure at the MRHD based on AUC)

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The New England Journal of Medicine, 387 (3), 205-216

Discussion The idea of GSH-induced hypopigmenta-tion may stem from early studies linking sulfhydral-containing compounds to the inhibition of melanogenesis or from early anecdotal observations in Parkinson's disease

DOI: 10.1016/S2468-1253(19)30324-3