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The question has gained visibility due to anecdotal accounts of so-called Ozempic babies. This paper aims to delineate mechanisms linking GLP-1 receptor activation with reproductive outcomes, review clinical data on fertility, and outline implications for practice

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Next, homologous recombination mediated systematic regional deletions from above selected BAC-reporter construct are carried out in bacterial cells and these modified constructs are again microinjected into mouse fertilized eggs to decisively evaluate the reporter activity in the developing mouse organisms: in this final step, rigorous assessment of how BAC deletion patterns affect reporter expression profiles reliably distinguishes critical regions for gene transcriptional regulations