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JAMA - J Am Med Assoc (2017) 318(23):230616

2024 Society of Black Academic Surgeons Annual Meeting, 2024

The plasma-to-cell cycle of transferrin

In Szary syndrome (see Chapter 145), the tumor cells produce IL-5 and, therefore, are responsible for the eosinophilia, which is a reflection of tumor burden.64 Where eosinophilia is a good prognostic factor, eosinophils are considered to be part of an effective host response to the tumor.65,66 The specific nature of eosinophil-dependent antitumor activity has not been sufficiently explored but may include, in addition to direct cytotoxic effects on tumor cells, tumor antigen presentation, vascular compromise via microthrombi formation, or synergism with the antitumor response of other leukocytes