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The seven upregulated fatty acids consisted of four saturated fatty acids (i.e., myristic acid, stearic acid, palmitic acid, and eicosanoic acid) and three unsaturated fatty acids (i.e., oleic acid, 11-octadecanoic acid, and 10-undecynoic acid), while the five downregulated fatty acids included three saturated fatty acids (i.e., oxiraneundecanoic acid, oxiraneoctanoic acid, and pentanoic acid) and two unsaturated fatty acids (i.e., palmitoleic acid and 11-hexadecenoic acid) (Figure 5G)

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In brief, in this study, we have assessed the impact of the 4 allele of the APOE gene and a mutation in PSEN1(G206D) on the cellular mechanisms underlying the pathogenesis of AD using skin fibroblasts derived from AD patients (Figure 7)

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