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Oral Steroids: For severe cases of hives, a short course of oral corticosteroids may be prescribed to reduce inflammation and control symptoms

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It also inhibits the enzyme tyrosinase, which is involved in melanin synthesis

Specifically, hypoxia upregulates HIF-2 in PAECs, leading to enhanced expression of the p53 protein, which subsequently increases the levels of cleaved Caspase-3 and promotes apoptosis

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Unfortunately, regular glutathione is notoriously fragile