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Over-the-counter numbing creams or gels can be applied to the injection site before the injection to help reduce pain

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SAM administered orally or by injection has been investigated as a treatment for liver diseases, osteoarthritis, and depression.6 The benefits bestowed by SAM may be due to its role as a methyl donor in biochemical processes governing lipid homeostasis, DNA stability, gene expression, and neurotransmitter release

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This procedure is the most definitive and durable procedure for relieving the pain