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Given these biological and methodological constraints, the field is increasingly turning toward multimodal strategies to capture the complexity of neuroprotection

10.1097/MCO.0b013e328333d157 329

A compromised gut barrier is both a cause and a consequence of dysbiosis, and intervening at the level of mucosal integrity, which is precisely what BPC-157 does in animal models, represents a mechanistically coherent approach to gut-mediated systemic aging

Furthermore, during demyelination iron is released from OLs and accumulates in the extracellular space, becoming available for the uptake by microglia and infiltrating macrophages (58)

To compensate for this sudden loss of blood pressure, the autonomic nervous system triggers severe tachycardia (a rapid heart rate), manifesting as Postural Orthostatic Tachycardia Syndrome (POTS) and other forms of dysautonomia