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38 In addition to BMPR2 mutation, downregulation of BMPR2 is of note for hyper-proliferation of PASMCs

Using the intranasal method in animal models, researchers have successfully reduced stroke damage, reversed Alzheimer's neurodegeneration, reduced anxiety, improved memory, and delivered neurotrophic factors and neural stem cells to the brain [30, 31, 34,35,36,37]

[DOI] [PMC free article] [PubMed] [Google Scholar] 130.Karagas NE & Venkatachalam K

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10.1093/annonc/mdv388 Ann

38 Downregulated signaling pathways AMPK signaling pathway AMPK is a pivotal serine/threonine protein kinase that plays an extensive role in the regulation of cellular energy metabolism 39