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Intranasal administration of a hematopoietic growth factor, which has limited capacity to cross the bloodbrain barrier, is 812 times more effective than subcutaneous application in brain and CSF delivery [83]

For the purposes of the present document, gene therapy involves the transfer of nucleic acid encoding a modified FX polypeptide provided herein

3.2 Network meta-analysis plot Figure 1 shows a network diagram of trials that tested the effectiveness of different interventions (placebo, Vitamin D, selenium supplements, inositol, Vitamin D + selenium, Vitamin D + inositol) and direct comparisons of these interventions

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Importantly, recent reports showed that about 211% of patients with COVID-19 had underlying chronic liver disease (Jothimani et al., 2020) and that abnormal liver function is rather common in the course of the malady