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PMID: 38 Bayet-RobertMKwiatkowskiFLeheurteurMGachonFPlanchatEAbrialCet al

Continuous use increases side effect risk and promotes desensitization

doi: 10.1016/j.pharmthera.2020.107520 135 RussoA

We observed the same in our cohort of 70 patients: compared to patient matched healthy tissue, tumors had significantly higher levels of GSSG which they appeared to redox-balance by enhancing GSH production, reflected by a an accumulation of GSH as well as its precursors (Fig