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Pack-years is estimated by multiplying the number of cigarette packs smoked a day times the number of years a person smoked

Annu Rev Physiol 71:451464 Rahman I, Marwick J, Kirkham P (2004) Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression

Its not too much of a leap here

It was one of the first blatantly anti-Nazi films to be produced in Hollywood, but according to film scholar Ben Urwand, "ultimately made very little impact" as it did not show the persecution experienced by Jews or name that ethnic group

Similarly, another study showed that tIRI triggered oxidative stress, thereby upregulating the phosphorylation of p53 and the expression of its downstream proapoptotic factor Puma, resulting in increased apoptosis

But the song is broader than a conventional love triangle