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destructor has spread worldwide after its host-shift from the Eastern honey bee ( Apis cerana ), T

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dataset showed that GPX4 demonstrated the highest variability (standard deviation of log2 fold changes = 0.39), followed by EIF3B (0.26) and ST3GAL1 (0.24)

Such heterogeneity complicates the development of universally effective therapies and underscores the need for personalized approaches, which currently face limitations due to an incomplete understanding of these individual determinants (164)

doi: 10.1056/NEJMoa1803917

It also reduces the intramitochondrial ratio of acetyl-CoA to free CoA, which in turn stimulates pyruvate dehydrogenase activity and promotes pyruvate oxidation