glutathione reductase catalytic mechanism catalysis and the reaction mechanisms of glutathione-dependent enzymes Catalytic cycle of GPx and

Cancer Chemother Pharmacol

The discovery in 2013 by Ostrem et al of a druggable pocket within the switch II region (S-IIP) of KRAS-G12C protein enabled the development of covalent inhibitors that selectively target the mutant cysteine residue in its GDP-bound state.24 This breakthrough led to the development of sotorasib (AMG 510) and adagrasib (MRTX849),13 2931 the first FDA-approved G12Ci for locally advanced or metastatic NSCLC

230 By comparing the transcriptomic profile of NSCLC A549 cells exposed to cytotoxic doses of CDDP, cadmium dichloride (CdCl 2 , an environmental pollutant that triggers oxidative stress-dependent apoptosis) and C 2 -ceramide (a plasma membrane permeant ceramide with mitochondriotoxic effects), we have recently demonstrated that CDDP elicits signaling cascades (encompassing both pro-survival and pro-death pathways) that are for the most part private, that is, they manifest limited overlap with the molecular mechanisms set in motion by other inducers of mitochondrial apoptosis

Ishigaki, W

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