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Jackson et al., 2003

In addition to directly suppressing OS, MT inhibits pyroptosis mediated by the NLRP3/GSDMD pathway, reduces inflammation, and activates the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway to strengthen endogenous antioxidant defenses, ultimately exhibiting both anticonvulsant and antidepressant effects (Tchekalarova et al., 2020)