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neoformans secretes extracellular urease to modulate phagosomal pH, which in turn promotes the conditions necessary for melanization, persistence in phagocytic cells, and eventual traversal of the blood-brain barrier 34

Mayo Clin Proc 61: 978996

Each vial is manufactured under sterile conditions and sealed for single or multi-use laboratory applications

However, several theoretical indirect mechanisms warrant clinical consideration

A dual role for Ca(2+) in autophagy regulation

Heme binding protein genes (44 out of the studied 121 genes) were also enriched in the upregulated gene set, while Fe-S cluster protein genes (14 out of the studied 43 genes) were enriched in the downregulated gene set (Additional file 2)