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According to the study, UA had a direct proinflammatory effect on human macrophages manifested by increased macrophage phagocytic activity, the production of TNF-alpha and toll-like receptor 4 (TLR4), and downregulated the urate anion transporter 1 expression. [ Uric acid is believed to contribute to the antioxidant potential in plasma but within the cell it is rather pro-oxidant

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The main rationale for cycling rather than continuous use involves conservative safety practices given limited long-term human data, cost management, and theoretical concerns about receptor desensitization with extended exposure

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Taiwan J Obstet Gynecol 52:161164 Peralta-Zaragoza O, Bermdez-Morales VH, Prez-Plasencia C et al (2012) Targeted treatments for cervical cancer: A review