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These effects may be achieved by lowering HR or by acting directly on -adrenergic receptors in VSMCs to relax the vessel tone or reduce catecholamine release from post-ganglionic sympathetic neurons (215)

We have also shown that primary lymphoma/leukemia cells from this mouse model and B-cell lymphoma/leukemia patients accumulate higher intracellular glutathione levels than non-tumor lymphocytes

173,174 PROM2 overexpression is strongly associated with the increased metastatic potential of melanoma, with similar results found in patient-derived xenotransplantation models of RCC and TNBC