Remarkably, paternal alcohol use appears to interact with maternal exposures to accelerate these mitochondrial deficits, promoting a sustained pro-inflammatory state, which increases offspring susceptibility to liver disease and hepatocellular carcinoma ( Our ongoing research indicates that chronic paternal alcohol consumption impairs mitochondrial function within the male reproductive tract, correlating with alterations in sperm noncoding RNAs and long-lasting changes in offspring mitochondrial activity ( Antioxidant therapies aim to mitigate oxidative stress, a condition characterized by an imbalance between reactive oxygen species and the cellular antioxidant defense ( Although healthy men commonly use antioxidants through their widespread incorporation into multivitamins and dietary supplements, in the absence of oxidative stress, this indiscriminate use may induce significant epigenetic alterations in the male germline, raising clinical and public health concerns ( N-acetyl-L-cysteine (NAC) and selenium (Se) are two widely studied antioxidant compounds used to investigate cellular responses to oxidative stress
For example, a study published in the European Journal of Nutrition found that oral supplementation with S-acetyl L-glutathione was effective in increasing body stores of glutathione, with significant increases observed in lymphocytes and buccal cells
35,39,40 This also proved the great potential of combining photothermal effect with ROS generated by Fenton reaction for synergistic cancer therapy
and Cornus officinalis on hyperuricemia-induced HepG2 cells, renal cells, and mice
In this study, we explored the anti-aging and neuroprotective effect of SalA in a model of age-related A42-induced neurodegeneration in Drosophila
Appl Environ Microbiol 76(8):24332438
