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Other systemic strategies exert comparable effects: regular exercise reduces circulating glucose levels at the expense of tumors 204 , and adrenergic activation in brown adipose tissue suppresses tumor growth by increasing host glucose utilization 205

Recent studies indicate that PHGDH expression is reduced by 40-50% in 1p/19q-codeleted gliomas compared to non-codeleted gliomas, suggesting these gliomas have selective vulnerability to serine and glutathione depletion (103)