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GSEA [32] was conducted using the Hallmark gene sets [33]

Delta Sleep-Inducing Peptide (DSIP) is a nine-amino acid regulatory neuropeptide first identified in 1977 by Marcel Monnier and colleagues at the University of Basel, isolated from the cerebral venous blood of rabbits following low-frequency hypnogenic electrical stimulation of the intralaminar thalamic nuclei

PNAS 95: 7805-7812

In the subsequent secretory phase, elevated levels of P4 promote cellular differentiation, transforming the endometrium into a receptive state, thereby inducing the secretion of pro-implantation molecules and proteins

Nature 528, 262266

Following intriguing outcomes from in vivo studies on Epitalon treatment for retinitis pigmentosa [18,19,20], the molecular mechanism of Epitalon was further examined