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conducted a prospective, population-based study, which showed that a lower 25-(OH)D circulating concentration and a higher parathyroid hormone (PTH) concentration increased the risk of sarcopenia (loss of hand grip strength and loss of appendicular skeletal muscle mass) in old age [78]

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Nat Rev Genet 13:358369 Prot JM, Briffaut A-S, Letourneur F, Chafey P, Merlier F, Grandvalet Y, Legallais C, Leclerc E (2011) Integrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochip

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The theory is elegant: target fat cells directly by activating the same pathway that GH uses to stimulate fat release, without elevated IGF-1 or blood sugar concerns