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However, these peptides did not represent fully optimized stapled peptides as they exhibited off-target effects in multi-day cell proliferation studies (Fig

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Canakinumab in the treatment of erosive hand osteoarthritis: a case series

P., & Bostwick, J

Gastroenterology 108:761 Ruenzi M, Stolte M, Veljaca M, Oreskovic K, Peterson J, Ulcerative Colitis Study Group (2005) A multicenter, randomized, double blind, placebo-controlled phase II study of PL 14736 enema in the treatment of mild-to-moderate ulcerative colitis

The IVD is particularly prone to impaired repair leading to permanent damage