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The researchers identified the PI3K/AKT signaling pathway as a key mechanism mediating Dihexa's cognitive benefits, expanding the mechanistic understanding beyond the original HGF/c-Met focus

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10.1002/brb3.1726 148 WalterM

doi: 10.1089/met.2023.0034 94 RasmussenMHHvidbergAJuulAMainKMGotfredsenASkakkebaekNEet al

one or more NNMT inhibitors such as a cation of Formula I or IA, or otherwise disclosed herein one or more chemical entities e.g., nicotinamide riboside, nicotinamide mononucleotide one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT followed by contacting said cell expressing NNMT with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulate intracellular NAD+ levels to provide muscular therapy

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