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459 Adipose tissue-specific Nampt knockin and knockout mice (ANKI and ANKO) showed opposite alterations of circulating eNAMPT, which accordingly affected hypothalamic NAD + /SIRT1 signaling and physical activity

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Humanin and related mitochondrial peptides have been linked to reduced oxidative stress in spermatozoa, improving motility and DNA integrity in lab studies

Only a few of the variants showed a decrease in affinity, which might be due to the selected mutations being distant from the CDR region