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During disease progression, circulating immune cells such as monocytes and lymphocytes infiltrate the synovial membrane, triggering a cascade of pro-inflammatory signals that manifest clinically as joint swelling

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GSH level was assayed based on the method of Beutler et al

Activity Modification & Education Cross-training with low-impact activities (cycling, swimming, elliptical) during recovery Gradual return to higher-level sports as pain and function improve Comprehensive patient education on ergonomics, technique, and recurrence prevention 4

Overall, these results suggest that a subset of chloracetamides with diverse chemical structures engages GPX4 to induce ferroptosis (Fig