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It can be a reduction in proprioception, the bodys ability to sense position and movement

Some users of tirzepatide and semaglutide have reported exactly this pattern

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Zakharenko SS, Patterson SL, Dragatsis I, Zeitlin SO, Siegelbaum SA, Kandel ER, Morozov A (2003) Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapses

A 2024 pharmaceutical review in Pharmaceuticals raised concerns that VEGF and VEGFR2 pathway activation in patients with undetected cancers presents a plausible, though unconfirmed, oncological risk