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Aging reduces NAD+ synthesis pathways while increasing consumption by enzymes like CD38 and PARPs, activated by inflammation and damage.[13][15] CD38, an immune-related enzyme, ramps up with age, breaking down NAD+ precursors

Additional obstacles are the slow growth of NCs and their sensitivity to the external environment [58]

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Another reason why NAD+ supplements are not recommended is because the molecule is unstable, degrading rapidly when exposed to light, moisture, or heat

Some individuals may struggle to absorb B12 through diet alone especially those with certain dietary restrictions or medical conditions

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