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The amide backbones of the mutant Ala253 residues in adjacent activation loops are separated by 17 , and both of the alanine side chains face inward, toward the center of the tetramer

Pol Merkur Lekarski 48(284):124127 Alkadi H (2020) A review on free radicals and antioxidants

In vitro studies have investigated the neuroprotective effects of statins, particularly focusing on RGCs and their progressive loss due to apoptosis in glaucoma

This suggests that hepatotoxicity will occur if the patient is not treated properly (normal serum half-life = 2.02.5 hours

Aronica L, Ordovas JM, Volkov A, Lamb JJ, Stone PM, Minich D, Leary M, Class M, Metti D, Larson IA, Contractor N, Eck B, Bland JS (2022) Genetic biomarkers of metabolic detoxification for personalized lifestyle medicine

You can see the location of this nerve in the following image