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Pernicious anaemia and deficiency with neurological involvement require more intensive treatment with alternate-day injections until improvement, followed by lifelong maintenance

Personalized Treatment Individual factors such as metabolic rate, existing health conditions, and specific nutritional deficiencies can all influence how well and quickly these injections work

Although B12 is the only one of the water-soluble vitamins that can be stored in the body (mainly in the liver), it does not appear to accumulate negatively

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For instance, the NICE guideline says that with total B12 values of over 350 ng/L,0 deficiency is unlikely

After that, it becomes once every 3-4 days over the course of 3 weeks