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Keap1 gene deletion exclusively in renal tubular epithelial cells of mouse embryos also induced polyuria and hydronephrosis after birth [69,70]

In addition to selenium, studies in vitro on the effect of other antioxidant agents provided, at least in part, interesting results which, unfortunately, have not been yet completely confirmed by clinical studies

However, abnormally high amounts could cause kidney damage and higher incidence of diarrhea and headaches

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Biochem Biophys Res Commun 201:748755 Markulin L, Corbin C, Renouard S, Drouet S, Gutierrez L, Mateljak I, Auguin D, Hano C, Fuss E, Laine E (2019) Pinoresinol-lariciresinol reductases, key to the lignan synthesis in plants